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4-chlorophenyl salicylate

  • Chemical Name: 4-chlorophenyl salicylate
  • CAS: 2944-58-3
  • Purity: 99%
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  • Molecular Formula: C13H9 Cl O3
  • Molecular Weight: 248.666
  • Vapor Pressure: 1.7E-05mmHg at 25°C 
  • Boiling Point: 353.9ºC at 760 mmHg 
  • Flash Point: 167.9ºC 
  • PSA: 46.53000 
  • Density: 1.357g/cm3 
  • LogP: 3.26480 

4-chlorophenyl salicylate(Cas 2944-58-3) Usage

General Description

4-Chlorophenyl salicylate, also known as mexenone, is a chemical compound that belongs to the class of organic compounds known as salicylic acids and derivatives. It is a white crystalline solid that is used as a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is commonly used for the treatment of pain, inflammation, and fever. 4-Chlorophenyl salicylate works by inhibiting the production of prostaglandins, which are substances in the body that cause pain and inflammation. It is often used in combination with other medications such as acetaminophen or codeine for enhanced pain relief. However, like other NSAIDs, it may have side effects such as gastrointestinal irritation, allergic reactions, or liver problems and should be used with caution and under the supervision of a healthcare professional.

InChI:InChI=1/C13H9ClO3/c14-9-5-7-10(8-6-9)17-13(16)11-3-1-2-4-12(11)15/h1-8,15H

2944-58-3 Relevant articles

Synthesis of salicylates from anionically activated aromatic trifluoromethyl group

Lin, Chuankai,Liu, Jin-Biao,Wang, Ruixiang,Xie, Huilin

supporting information, (2021/12/22)

An efficient approach to salicylates via...

Cerium photocatalyzed radical smiles rearrangement of 2-aryloxybenzoic acids

Tripathy, Alisha Rani,Yatham, Veera Reddy,Yedase, Girish Suresh

, p. 25207 - 25210 (2021/08/05)

We report herein a cerium photocatalyzed...

N-Heterocyclic carbene/photo-cocatalyzed oxidative Smiles rearrangement: Synthesis of aryl salicylates from: O -aryl salicylaldehydes

Xia, Zi-Hao,Dai, Lei,Gao, Zhong-Hua,Ye, Song

supporting information, p. 1525 - 1528 (2020/02/13)

The N-heterocyclic carbene/photo-cocatal...

Efficient Aryl Migration from an Aryl Ether to a Carboxylic Acid Group To Form an Ester by Visible-Light Photoredox Catalysis

Wang, Shao-Feng,Cao, Xiao-Ping,Li, Yang

, p. 13809 - 13813 (2017/10/24)

We have developed a highly efficient ary...

2944-58-3 Process route

2-(trifluoromethyl)phenol
444-30-4

2-(trifluoromethyl)phenol

4-chloro-phenol
106-48-9,82344-39-6

4-chloro-phenol

4-chlorophenyl 2-hydroxybenzoate
2944-58-3

4-chlorophenyl 2-hydroxybenzoate

Conditions
Conditions Yield
With water; potassium carbonate; In toluene; at 120 ℃; for 12h;
91%
4-chlorophenyl 2-methylpropionate
104316-24-7

4-chlorophenyl 2-methylpropionate

salicylic acid
69-72-7,25496-36-0,8052-31-1

salicylic acid

4-chlorophenyl 2-hydroxybenzoate
2944-58-3

4-chlorophenyl 2-hydroxybenzoate

Conditions
Conditions Yield
With phosphomolybdic acid; In 5,5-dimethyl-1,3-cyclohexadiene; at 110 ℃; for 10h;
79%

2944-58-3 Upstream products

  • 106-48-9
    106-48-9

    4-chloro-phenol

  • 69-72-7
    69-72-7

    salicylic acid

  • 6410-65-7
    6410-65-7

    2-(4-chloro-phenoxy)-benzoic acid

  • 88-67-5
    88-67-5

    2-Iodobenzoic acid

2944-58-3 Downstream products

  • 88599-62-6
    88599-62-6

    2-Carbamoyloxy-benzoic acid 4-chloro-phenyl ester

  • 128916-07-4
    128916-07-4

    2-Allyloxy-benzoic acid 4-chloro-phenyl ester

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